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 | Issue Date FY: 2025 ( Subtotal = $83,765,779 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI178613 | Larval Ecology of Invasive Anopheles stephensi in Ethiopia | 000 | 2 | NIH | 12/3/2024 | $215,127 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DE033732 | Impact of Pregnancy Dental Benefits on Dental Care Utilization among Pregnant Women and Young Children | 001 | 2 | NIH | 5/8/2025 | $44,899 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DE033732 | Impact of Pregnancy Dental Benefits on Dental Care Utilization among Pregnant Women and Young Children | 000 | 2 | NIH | 3/26/2025 | $404,095 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 001 | 5 | NIH | 4/11/2025 | $24,900 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 000 | 5 | NIH | 1/8/2025 | $224,100 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR005032 | Autonomous Platform for Pulsatile Soluble Stimulation | 000 | 2 | NIH | 3/13/2025 | $211,950 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI158503 | Developing broad-spectrum therapeutics against C. difficile toxins | 000 | 5 | NIH | 1/10/2025 | $748,253 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG082127 | Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions | 001 | 3 | NIH | 3/7/2025 | $1,817,870 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K22CA272915 | Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites | 000 | 3 | NIH | 11/22/2024 | $142,625 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM148236 | Accelerating drug discovery via ML-guided iterative design and optimization | 001 | 3 | NIH | 3/24/2025 | $531,346 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HD115268 | Decoding the Mechanism of Pathogenic Enhancer Mutations In Congenital Limb Disorders | 000 | 2 | NIH | 4/3/2025 | $404,190 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA280606 | Mechanisms of treatment-free remission in a mouse model of chronic myeloid leukemia | 001 | 2 | NIH | 5/22/2025 | $35,914 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA280606 | Mechanisms of treatment-free remission in a mouse model of chronic myeloid leukemia | 000 | 2 | NIH | 4/10/2025 | $323,224 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | UG3CA290368 | Nautral products for targeting Skp2 in cancer interception | 001 | 2 | NIH | 5/22/2025 | $33,362 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | UG3CA290368 | Nautral products for targeting Skp2 in cancer interception | 000 | 2 | NIH | 3/28/2025 | $300,263 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG072587 | Structural and Biological Characterization of Diverse Oligomers Derived from Abeta | 000 | 3 | NIH | 4/1/2025 | $396,728 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI178440 | Serological Biomarkers for Monitoring Human-Vector Contact by Invasive Anopheles stephensi in Africa | 000 | 2 | NIH | 11/29/2024 | $190,363 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI173023 | Investigating protective adaptive immune responses to influenza antigens using human tonsil organoids | 000 | 3 | NIH | 5/30/2025 | $610,039 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI177428 | Structural studies of the OrfX-type progenitor toxin complex of botulinum neurotoxin | 000 | 1 | NIH | 2/25/2025 | $616,816 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 002 | 4 | NIH | 4/10/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 001 | 4 | NIH | 3/12/2025 | $366,163 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 003 | 4 | NIH | 5/22/2025 | $40,684 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM157311 | Defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense | 000 | 1 | NIH | 1/31/2025 | $379,823 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH126285 | Nucleus accumbens circuits for regulating cue-motivated behavior | 000 | 5 | NIH | 3/11/2025 | $540,053 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA193466 | Computational and Experimental Modeling of Alternative Polyadenylation | 001 | 10 | NIH | 5/22/2025 | $36,031 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA193466 | Computational and Experimental Modeling of Alternative Polyadenylation | 000 | 10 | NIH | 2/14/2025 | $324,276 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI185349 | The Role of Interferon Lambda in Alpha Herpesvirus Neuroinvasion | 000 | 1 | NIH | 1/27/2025 | $471,159 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM153231 | Development of new methods and strategies for the synthesis of complex molecules | 001 | 2 | NIH | 1/8/2025 | $336,303 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32HD114452 | Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department | 000 | 2 | NIH | 1/20/2025 | $78,328 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS121227 | Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration | 000 | 4 | NIH | 12/23/2024 | $505,515 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA272680 | Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients | 000 | 3 | NIH | 12/6/2024 | $551,777 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA283575 | Targeting Metabolic Crosstalk in Pancreatic Cancer | 001 | 2 | NIH | 5/22/2025 | $44,533 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA283575 | Targeting Metabolic Crosstalk in Pancreatic Cancer | 000 | 2 | NIH | 4/10/2025 | $400,786 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U19AI172725 | MDRO Carriage, Transmission, Sequelae, and Prevention in Nursing Homes | 001 | 3 | NIH | 5/9/2025 | $3,252,905 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01AI180164 | Impact of aging on human B cell vaccine responses | 000 | 2 | NIH | 4/17/2025 | $565,200 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01EY034594 | Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE) | 000 | 3 | NIH | 3/27/2025 | $393,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01HG011745 | Pediatric Mendelian Genomics Research Center | 000 | 5 | NIH | 5/1/2025 | $2,074,563 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35NS122140 | La Spada Outstanding Investigator Award | 000 | 5 | NIH | 5/9/2025 | $1,162,302 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HD113752 | STRESS, MEMORY, AND RUMINATION IN MALTREATED ADOLESCENTS | 000 | 2 | NIH | 4/16/2025 | $617,307 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS130044 | Investigation of neural ensembles driving pain chronification | 000 | 3 | NIH | 11/8/2024 | $304,346 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01ES025767 | Toxicological importance of CYP3A4 catalysis and inhibition | 000 | 9 | NIH | 1/13/2025 | $561,595 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U24MH133236 | UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents | 000 | 3 | NIH | 4/25/2025 | $945,779 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM149572 | Molecular Mechanisms of Telomere Length Homeostasis | 001 | 3 | NIH | 4/11/2025 | $392,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R33HD102988 | Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings | 000 | 3 | NIH | 1/8/2025 | $300,417 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30EY033642 | microRNA-204 and microRNA-211 regulation of RPE phagocytosis | 000 | 4 | NIH | 12/6/2024 | $53,974 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG082485 | Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model | 001 | 2 | NIH | 5/29/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL153724 | The state of energy in the right ventricle of patients with pulmonary arterial hypertension | 002 | 4 | NIH | 3/12/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG082485 | Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model | 000 | 2 | NIH | 11/14/2024 | $45,458 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL153724 | The state of energy in the right ventricle of patients with pulmonary arterial hypertension | 001 | 4 | NIH | 12/19/2024 | $561,825 |
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